Publications
2023
A geometrical perspective on development
Raju A, Siggia E. A geometrical perspective on development. Development Growth and Differentiation. 2023;
2022
Mechanisms underlying WNT-mediated priming of human embryonic stem cells
Yoney A, Bai L, Brivanlou A, Siggia E. Mechanisms underlying WNT-mediated priming of human embryonic stem cells. Development (Cambridge). 2022;149(20).
Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington's disease models
Metzger J, Pereda C, Adhikari A, Haremaki T, Galgoczi S, Siggia E, et al. Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models. Cell Reports Methods. 2022;2(9).
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells
Simunovic M, Siggia E, Brivanlou A. In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells. Cell Stem Cell. 2022;29(6):962-972.e4,.
Mechanical regulation of early vertebrate embryogenesis
Valet M, Siggia E, Brivanlou A. Mechanical regulation of early vertebrate embryogenesis. Nature Reviews Molecular Cell Biology. 2022;23(3):169-184,.
Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions
Sáez M, Blassberg R, Camacho-Aguilar E, Siggia E, Rand D, Briscoe J. Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. Cell Systems. 2022;13(1):12-28.e3,.
2021
Human neural tube morphogenesis in vitro by geometric constraints
Karzbrun E, Khankhel A, Megale H, Glasauer S, Wyle Y, Britton G, et al. Human neural tube morphogenesis in vitro by geometric constraints. Nature. 2021;599(7884):268-272,.
Geometry of gene regulatory dynamics
Rand D, Raju A, Sáez M, Corson F, Siggia E. Geometry of gene regulatory dynamics. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(38).
Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport
Phan-Everson T, Etoc F, Li S, Khodursky S, Yoney A, Brivanlou A, et al. Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport. Developmental Cell. 2021;56(13):1930-1944.e5,.
2020
In vitro modeling of early mammalian embryogenesis
Hadjantonakis AK, Siggia E, Simunovic M. In vitro modeling of early mammalian embryogenesis. Current Opinion in Biomedical Engineering. 2020;13:134-143,.