Publications
2019
A 3D model of a human epiblast reveals BMP4-driven symmetry breaking
Simunovic M, Metzger J, Etoc F, Yoney A, Ruzo A, Martyn I, et al. A 3D model of a human epiblast reveals BMP4-driven symmetry breaking. Nature Cell Biology. 2019;21(7):900-910,.
Self-organization of stem cells into embryos: A window on early mammalian development
Shahbazi M, Siggia E, Zernicka-Goetz M. Self-organization of stem cells into embryos: A window on early mammalian development. Science. 2019;364(6444):948-951,.
A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells
Martyn I, Brivanlou A, Siggia E. A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells. Development (Cambridge). 2019;146(6).
Mapping cell migrations and fates in a gastruloid model to the human primitive streak
Martyn I, Siggia E, Brivanlou A. Mapping cell migrations and fates in a gastruloid model to the human primitive streak. Development (Cambridge). 2019;146(17).
2018
Erratum to: Self-organization of a human organizer by combined Wnt and Nodal signalling (Nature, (2018), 558, 7708, (132-135), 10.1038/s41586-018-0150-y)
Martyn I, Kanno T, Ruzo A, Siggia E, Brivanlou A. Erratum to: Self-organization of a human organizer by combined Wnt and Nodal signalling (Nature, (2018), 558, 7708, (132-135), 10.1038/s41586-018-0150-y). Nature. 2018;564(7735):E10+.
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
Yoney A, Etoc F, Ruzo A, Carroll T, Metzger J, Martyn I, et al. WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids. eLife. 2018;7.
Self-organization of a human organizer by combined Wnt and Nodal signaling
Martyn I, Kanno T, Ruzo A, Siggia E, Brivanlou A. Self-organization of a human organizer by combined Wnt and Nodal signaling. Nature. 2018;558(7708):132-135,.
Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning
Morgani S, Metzger J, Nichols J, Siggia E, Hadjantonakis AK. Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning. eLife. 2018;7.
Modeling Mammalian Gastrulation With Embryonic Stem Cells
Siggia E, Warmflash A. Modeling Mammalian Gastrulation With Embryonic Stem Cells. Human Embryonic Stem Cells in Development. 2018;129:1-23,.
2017
Gene-free methodology for cell fate dynamics during development
Corson F, Siggia E. Gene-free methodology for cell fate dynamics during development. eLife. 2017;6.